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DosingCalc

Tesamorelin reconstitution calculator

Tesamorelin (brand Egrifta, Egrifta SV, Egrifta WR; developmental code TH9507) is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary to release endogenous growth hormone. It is FDA-approved to reduce excess visceral abdominal fat in HIV-infected patients with lipodystrophy, where a 26-week trial cut visceral adipose tissue by roughly 15% versus a 5% increase on placebo (Falutz 2007, N Engl J Med, PMID 18057338). It is a lyophilized powder reconstituted before once-daily subcutaneous injection, with a very short elimination half-life of about 8-11 minutes and subcutaneous bioavailability under 4% per the Egrifta SV/WR FDA labels (DailyMed 2024).

By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.

Half-life

0.13 hours

Storage

2-8°C refrigerated

Route

subcutaneous

Shelf life

14 days

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Common side effects

arthralgia (joint pain), injection site erythema and pruritus, pain in extremity, peripheral edema / fluid retention, myalgia, elevated IGF-1, glucose intolerance, headache, carpal tunnel-type symptoms

Common vial sizes

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Frequently asked questions

How much bacteriostatic water should I add to Tesamorelin?

For a 10mg vial of Tesamorelin, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.

What is the typical Tesamorelin dosage?

Typical research dosages for Tesamorelin range from 1000 to 2000 mcg, administered once daily.

How long does reconstituted Tesamorelin last?

Reconstituted Tesamorelin should be stored at 2-8°C refrigerated and used within 14 days. Unreconstituted vials can be stored for up to 24 months.