PT-141 reconstitution calculator
Melanocortin receptor agonist studied for sexual dysfunction. Acts on the CNS, not the vascular system. FDA-approved as Vyleesi at 1.75 mg SC for HSDD in premenopausal women (bremelanotide USPI, FDA 2019). Contraindicated in uncontrolled hypertension, known cardiovascular disease, and pregnancy (Vyleesi USPI §4-§5.1, §8.1). Reduces oral naltrexone exposure ~60%; avoid in patients on naltrexone for opioid use disorder (Vyleesi USPI §7.1).
By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.
Medically reviewed by Elena Whitmore, PharmD.
Half-life
2.5 hours
Storage
2-8°C refrigerated
Route
subcutaneous
Shelf life
28 days
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Common side effects
nausea, flushing, headache, transient blood pressure elevation, focal hyperpigmentation (face, gums, breasts; sometimes irreversible)
What you need
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Syringes
30G 1cc 1/2" Insulin Syringes
30-gauge needle, 1ml capacity, 1/2" length. Most versatile size for peptide dosing. Common brands: Brandzig, Easy Touch, Care Touch.
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30G 0.5cc Insulin Syringes
0.5ml capacity with finer markings and bold graduation numbers. Better for small doses under 50 units.
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Bacteriostatic Water
Storage
Mini Fridge for Peptide Storage
Dedicated peptide fridge keeps vials at 2-8°C without opening the kitchen door 12 times a day. The Cooluli 4L is the staple pick.
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3mL Peptide Vial Storage Case
10-slot transparent holder for 1-3mL vials. Keeps reconstituted peptides organized in the fridge and visible at a glance.
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Common vial sizes
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Frequently asked questions
How much bacteriostatic water should I add to PT-141?
For a 10mg vial of PT-141, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.
What is the typical PT-141 dosage?
Typical research dosages for PT-141 range from 500 to 1750 mcg, administered As needed, 30-45 min before.
How long does reconstituted PT-141 last?
Reconstituted PT-141 should be stored at 2-8°C refrigerated and used within 28 days. Unreconstituted vials can be stored for up to 24 months.
How do I calculate my PT-141 dose?
Divide your target dose by the concentration to get the volume, then multiply by 100 for units on a U-100 insulin syringe. For example, a 10mg vial in 2ml of bacteriostatic water gives 5000 mcg/ml. The calculator above does this automatically once you enter your vial size, water volume, and desired dose.
How many units of PT-141 should I draw on an insulin syringe?
On a U-100 insulin syringe, 1 unit equals 0.01 ml regardless of the barrel size (0.3ml, 0.5ml, or 1ml). Enter your reconstitution details in the calculator to see the exact number of units to draw for your dose.