PT-141 reconstitution calculator
Melanocortin receptor agonist studied for sexual dysfunction. Acts on the CNS, not the vascular system. FDA-approved as Vyleesi at 1.75 mg SC for HSDD in premenopausal women (bremelanotide USPI, FDA 2019). Contraindicated in uncontrolled hypertension, known cardiovascular disease, and pregnancy (Vyleesi USPI §4-§5.1, §8.1). Reduces oral naltrexone exposure ~60%; avoid in patients on naltrexone for opioid use disorder (Vyleesi USPI §7.1).
By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.
Half-life
2.5 hours
Storage
2-8°C refrigerated
Route
subcutaneous
Shelf life
28 days
Common side effects
nausea, flushing, headache, transient blood pressure elevation, focal hyperpigmentation (face, gums, breasts; sometimes irreversible)
What you need
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Syringes
30G 1cc 1/2" Insulin Syringes
30-gauge needle, 1ml capacity, 1/2" length. Most versatile size for peptide dosing. Common brands: Brandzig, Easy Touch, Care Touch.
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30G 0.5cc Insulin Syringes
0.5ml capacity with finer markings and bold graduation numbers. Better for small doses under 50 units.
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Bacteriostatic Water
Common vial sizes
Frequently asked questions
How much bacteriostatic water should I add to PT-141?
For a 10mg vial of PT-141, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.
What is the typical PT-141 dosage?
Typical research dosages for PT-141 range from 500 to 1750 mcg, administered As needed, 30-45 min before.
How long does reconstituted PT-141 last?
Reconstituted PT-141 should be stored at 2-8°C refrigerated and used within 28 days. Unreconstituted vials can be stored for up to 24 months.