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DosingCalc

HCG reconstitution calculator

Human chorionic gonadotropin, an LH-analog glycoprotein hormone that stimulates testicular Leydig cells to produce testosterone. Low-dose HCG (125-500 IU every other day) maintained intratesticular testosterone during testosterone-induced gonadotropin suppression in normal men (Coviello, J Clin Endocrinol Metab 2005, PMID 15713727); it is also used to restore spermatogenesis and fertility in hypogonadotropic hypogonadism. Dosed in international units (IU), not mg. Standard reconstitution is 5000 IU + 2 ml bacteriostatic water = 2500 IU/ml, so 250 IU = 0.1 ml = 10 units on a U-100 insulin syringe.

By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.

Medically reviewed by Elena Whitmore, PharmD.

Half-life

1.4 days

Storage

2-8°C refrigerated

Route

both

Shelf life

30 days

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Common side effects

injection site reactions, gynecomastia, acne, water retention, mood changes, testicular pain

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Frequently asked questions

How much bacteriostatic water should I add to HCG?

For a 5000IU vial of HCG, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.

What is the typical HCG dosage?

Typical research dosages for HCG range from 250 to 1500 IU, administered 2-3x weekly (EOD).

How long does reconstituted HCG last?

Reconstituted HCG should be stored at 2-8°C refrigerated and used within 30 days. Unreconstituted vials can be stored for up to 24 months.

How do I calculate my HCG dose?

Divide your target dose by the concentration to get the volume, then multiply by 100 for units on a U-100 insulin syringe. For example, a 5000IU vial in 2ml of bacteriostatic water gives 2500 IU/ml. The calculator above does this automatically once you enter your vial size, water volume, and desired dose.

How many units of HCG should I draw on an insulin syringe?

On a U-100 insulin syringe, 1 unit equals 0.01 ml regardless of the barrel size (0.3ml, 0.5ml, or 1ml). Enter your reconstitution details in the calculator to see the exact number of units to draw for your dose.