Tirzepatide (Mounjaro / Zepbound) dose calculator
Dual GIP/GLP-1 receptor agonist. Dosed weekly with titration starting at 2.5 mg per the Mounjaro/Zepbound labels (FDA 2024). SURMOUNT-1 (Jastreboff NEJM 2022, PMID 35658024) reported ~20.9% mean weight loss at 15 mg/72 weeks; SURPASS-2 (Frias NEJM 2021, PMID 34170647) showed stronger glycemic + weight effects vs semaglutide head-to-head.
By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.
Half-life
4.8 days
Storage
2-8°C refrigerated
Route
subcutaneous
Shelf life
28 days
Common side effects
nausea, diarrhea, decreased appetite, pancreatitis (rare but serious), thyroid C-cell tumors (boxed warning)
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Bacteriostatic Water
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Frequently asked questions
How much bacteriostatic water should I add to Tirzepatide?
For a 10mg vial of Tirzepatide, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.
What is the typical Tirzepatide dosage?
Typical research dosages for Tirzepatide range from 2500 to 15000 mcg, administered 1x weekly.
How long does reconstituted Tirzepatide last?
Reconstituted Tirzepatide should be stored at 2-8°C refrigerated and used within 28 days. Unreconstituted vials can be stored for up to 24 months.