Tirzepatide (Mounjaro / Zepbound) dose calculator
Dual GIP/GLP-1 receptor agonist. Dosed weekly with titration starting at 2.5 mg per the Mounjaro/Zepbound labels (FDA 2024). SURMOUNT-1 (Jastreboff NEJM 2022, PMID 35658024) reported ~20.9% mean weight loss at 15 mg/72 weeks; SURPASS-2 (Frias NEJM 2021, PMID 34170647) showed stronger glycemic + weight effects vs semaglutide head-to-head.
By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.
Medically reviewed by Elena Whitmore, PharmD.
Half-life
4.8 days
Storage
2-8°C refrigerated
Route
subcutaneous
Shelf life
28 days
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Common side effects
nausea, diarrhea, decreased appetite, pancreatitis (rare but serious), thyroid C-cell tumors (boxed warning)
What you need
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Syringes
30G 1cc 1/2" Insulin Syringes
30-gauge needle, 1ml capacity, 1/2" length. Most versatile size for peptide dosing. Common brands: Brandzig, Easy Touch, Care Touch.
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30G 0.5cc Insulin Syringes
0.5ml capacity with finer markings and bold graduation numbers. Better for small doses under 50 units.
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Bacteriostatic Water
Storage
Mini Fridge for Peptide Storage
Dedicated peptide fridge keeps vials at 2-8°C without opening the kitchen door 12 times a day. The Cooluli 4L is the staple pick.
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3mL Peptide Vial Storage Case
10-slot transparent holder for 1-3mL vials. Keeps reconstituted peptides organized in the fridge and visible at a glance.
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Frequently asked questions
How much bacteriostatic water should I add to Tirzepatide?
For a 10mg vial of Tirzepatide, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.
What is the typical Tirzepatide dosage?
Typical research dosages for Tirzepatide range from 2500 to 15000 mcg, administered 1x weekly.
How long does reconstituted Tirzepatide last?
Reconstituted Tirzepatide should be stored at 2-8°C refrigerated and used within 28 days. Unreconstituted vials can be stored for up to 24 months.
How do I calculate my Tirzepatide dose?
Divide your target dose by the concentration to get the volume, then multiply by 100 for units on a U-100 insulin syringe. For example, a 10mg vial in 2ml of bacteriostatic water gives 5000 mcg/ml. The calculator above does this automatically once you enter your vial size, water volume, and desired dose.
How many units of Tirzepatide should I draw on an insulin syringe?
On a U-100 insulin syringe, 1 unit equals 0.01 ml regardless of the barrel size (0.3ml, 0.5ml, or 1ml). Enter your reconstitution details in the calculator to see the exact number of units to draw for your dose.