Survodutide dose calculator
Investigational glucagon receptor / GLP-1 receptor dual agonist (BI 456906) from Boehringer Ingelheim, acylated with a C18 fatty-acid chain for once-weekly dosing (~6-7 day half-life). A phase 2 dose-finding obesity trial (le Roux, Lancet Diabetes Endocrinol 2024, PMID 38330987) reported up to ~18.7% mean weight loss at 4.8 mg weekly over 46 weeks; a phase 2 MASH trial (Sanyal, NEJM 2024, PMID 38847460) showed fibrosis improvement at 2.4-6.0 mg weekly. Titrated up from 0.6 mg to limit GI effects; not FDA/EMA approved (phase 3 SYNCHRONIZE program ongoing).
By the DosingCalc editorial team. Numbers and dose ranges are checked against the sources listed on our editorial standards page.
Medically reviewed by Elena Whitmore, PharmD.
Half-life
6.5 days
Storage
2-8°C refrigerated
Route
subcutaneous
Shelf life
28 days
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Common side effects
nausea, vomiting, diarrhea, constipation, decreased appetite, increased heart rate, injection site reactions
What you need
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Syringes
30G 1cc 1/2" Insulin Syringes
30-gauge needle, 1ml capacity, 1/2" length. Most versatile size for peptide dosing. Common brands: Brandzig, Easy Touch, Care Touch.
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30G 0.5cc Insulin Syringes
0.5ml capacity with finer markings and bold graduation numbers. Better for small doses under 50 units.
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Bacteriostatic Water
Storage
Mini Fridge for Peptide Storage
Dedicated peptide fridge keeps vials at 2-8°C without opening the kitchen door 12 times a day. The Cooluli 4L is the staple pick.
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3mL Peptide Vial Storage Case
10-slot transparent holder for 1-3mL vials. Keeps reconstituted peptides organized in the fridge and visible at a glance.
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Frequently asked questions
How much bacteriostatic water should I add to Survodutide?
For a 10mg vial of Survodutide, add 2ml of bacteriostatic water. This concentration works well with a standard insulin syringe.
What is the typical Survodutide dosage?
Typical research dosages for Survodutide range from 600 to 6000 mcg, administered 1x weekly.
How long does reconstituted Survodutide last?
Reconstituted Survodutide should be stored at 2-8°C refrigerated and used within 28 days. Unreconstituted vials can be stored for up to 24 months.
How do I calculate my Survodutide dose?
Divide your target dose by the concentration to get the volume, then multiply by 100 for units on a U-100 insulin syringe. For example, a 10mg vial in 2ml of bacteriostatic water gives 5000 mcg/ml. The calculator above does this automatically once you enter your vial size, water volume, and desired dose.
How many units of Survodutide should I draw on an insulin syringe?
On a U-100 insulin syringe, 1 unit equals 0.01 ml regardless of the barrel size (0.3ml, 0.5ml, or 1ml). Enter your reconstitution details in the calculator to see the exact number of units to draw for your dose.